Mice challenged with a ketogenic diet were compared to mice fed a high-fat diet or a high-fat diet plus exercise. When challenged with a ketogenic diet, mice had reduced bodyweight and fat mass compared to high-fat-fed mice, and were similar to exercised, high-fat-fed mice. High-fat-fed, exercised and ketogenic-fed mice had mildly elevated blood glucose; conversely, ketogenic diet-fed mice were unique in having reduced serum insulin levels. Ketogenic diet-fed mice never developed mechanical allodynia contrary to mice fed a high-fat diet. Ketogenic diet fed mice also had increased epidermal axon density compared all other groups. When a ketogenic diet was used as an intervention, a ketogenic diet was unable to reverse high-fat fed-induced metabolic changes but was able to significantly reverse a high-fat diet-induced mechanical allodynia. As an intervention, a ketogenic diet also increased epidermal axon density. These results suggest a ketogenic diet can prevent certain complications of prediabetes and provides significant benefits to peripheral axons and sensory dysfunction. The growing epidemic of obesity and diabetes has led to a dramatic increase in various pain syndromes and a personal as well as economic burden.
Additionally, both exercise and ketogenic diet can stimulate anti-inflammatory signaling cascades and reduce chronic inflammation that occurs in response to a high-fat diet Ruskin et al. Please add information by going to Contribute to NoFructose. This suggests that, despite the elevated fat content in both the ketogenic and high-fat diets, these diets affect mechanical sensation very differently. Here, mice challenged with a high-fat diet predictably developed increased body weight and fat deposition, mildly increased blood glucose and increased insulin levels. Ryals, 1 Michelle Winter, 4 and Douglas E. A combination of ischaemia decreasing blood supply, compression and inflammation occurs in a peripheral nerve. Experimental diabetes research.
A combination of ischaemia decreasing blood supply, compression and inflammation occurs in a peripheral nerve. Given enough time, and with associated inflammation, the nerves themselves become scarred and lose their protective fat layer. That results in an ongoing progressive deterioration of function and symptoms. The model of fructose and polyunsaturated oils combining to give us the subintimal inflammation in every blood vessel promotes this concept. It creates the susceptibility to damage from even mild compression. The reversal of our dietary intake has the potential to improve some symptoms.