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These are claimed to help you lose weight, or at least make it easier to lose weight combined with other methods. Garcinia cambogia became popular worldwide after being featured on the Dr. Oz show in The skin of the fruit contains hydroxycitric acid HCA. This is the active ingredient in garcinia cambogia extract, which is marketed as a diet pill. How it works: Animal studies show that it can inhibit a fat-producing enzyme in the body and increase levels of serotonin, potentially helping to reduce cravings 1, 2.